Mesenchymal Stem Cells and in situ Cross-linkable Hydrogel Scaffolds for Bone Tissue Engineering

نویسندگان

  • Maria Cornelissen
  • Evi Lippens
  • Geert Vertenten
  • Heidi Declercq
  • Ives Swennen
  • Jan Luyten
  • Lieven Vlaminck
  • Frank Gasthuys
  • Etienne Schacht
چکیده

Galway, Ireland Mesenchymal Stem Cells and in situ Cross-linkable Hydrogel Scaffolds for Bone Tissue Engineering. Maria Cornelissen, Evi Lippens, Geert Vertenten2, Heidi Declercq, Ives Swennen3, Jan Luyten, Lieven Vlaminck2, Frank Gasthuys2, Etienne Schacht3. Corresponding Author: [email protected] Ghent University, Department of Basic Medical Sciences, Ghent, Belgium and 2Ghent University, Department Of Surgery and Anaesthesiology of Domestic Animals, Ghent, Belgium and 3 Ghent University, Polymer Chemistry and Biomaterials Research Group, Ghent, Belgium and VITO NV, Mol, Belgium

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of the effects of autologous adipose derived mesenchymal stem cells in combination with polyacrylamide hydrogel and nanohydroxyapatite scaffolds on healing in rabbit critical-sized radial bone defect model

Objective: In this study, the bone regeneration ability of polyacrylamide hydrogel and nanohydroxyapatite scaffolds (PAAH/NHA) and stem cells derived from adipose tissue (ADSCs) in the healing of critical sized bone defects in rabbit radius were assessed. Animals and procedures: 12 New Zealand white male rabbits were divided into 3 groups. The rabbits were anesthetized and 15 mm bone def...

متن کامل

PLLA/HA Nano composite scaffolds for stem cell proliferation and differentiation in tissue engineering

Abstract Due to their mulitpotency, Mesenchymal stem cells (MSCs), have the ability to proliferate and differentiate into multiple mesodermal tissues. The aim of this study was to isolate MSCs from human Umbilical Cord (hUCMSCs) to determine their osteogenic potential on nanofibrous scaffolds. To this end, Poly (L-lactic acid) (PLLA)/Nano hydroxyapatite (HA) composite nanofibrous scaffolds were...

متن کامل

Application of Nanoscaffolds and Mesenchymal Stem Cells in Tissue Engineering

Stem cell research has obtained much prominence in recent years for its therapeutic potential in dealing with serious diseases, many of which are essentially incurable by routine therapies. Mesenchymal stem cells with pluripotency and immunomodulatory properties are suitable candidates for tissue engineering and regenerative medicine. Today, nanofibrous scaffolds are widely used in tissue en...

متن کامل

Comparison of Proliferation and Osteoblast Differentiation of Marrow-Derived Mesenchymal Stem Cells on Nano- and Micro-Hydroxyapatite Contained Composite Scaffolds

Bones constructed by tissue engineering are being considered as valuable materials to be used for regeneration of large defects in natural bone. In an attempt to prepare a new bone construct, in this study, proliferation and bone differentiation of marrow-derived mesenchymal stem cells (MSCs) on our recently developed composite scaffolds of nano-, micro-hydroxyapatite/ poly(l-lactic acid) were ...

متن کامل

Aligned and random nanofibrous nanocomposite scaffolds for bone tissue engineering

Aligned and random nanocomposite nanofibrous scaffolds were electrospun from polycaprolactone (PCL), poly (vinyl alcohol) (PVA) and hydroxyapatite nanoparticles (nHA). The morphology and mechanical characteristics of the nanofibers were evaluated using scanning electron microscopy and tensile testing, respectively. Scanning electron microscopy revealed fibers with an average diameter of 123 ± 3...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010